ea0094oc5.6 | Adrenal and Cardiovascular | SFEBES2023
Al Disi Sara
, Ascione Raimondo
, Johnson Tom
, Sammut Eva
, Domenico Bruno Vito
, Khan Shazia
, Singh Trisha
, Baz Lopez Daniel
, James Carol-Ann
, Walker Brian
, Mills Nicholas
, Webster Scott
, Freeman Adrian
, Whittaker Andrew
, Andrew Ruth
, Gray Gillian
Glucocorticoids (GCs) protect cardiomyocytes immediately after myocardial infarction (MI), but GCs subsequently regenerated within the heart by 11β-hydroxysteroid dehydrogenase 1 (11βHSD1) are detrimental during infarct repair, with functional outcomes post-MI improved in mice lacking 11βHSD1. Pharmacological 11βHSD1 inhibition (AZD8329 50mg/kg, 11βHSD1i) was compared to standard clinical therapy (SCT) in a translational pig model (female, 11βHSD1...